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- **************************
- * Tropomyosins signature *
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-
- Tropomyosins [1,2] are family of closely related proteins present in muscle
- and non-muscle cells. In striated muscle, tropomyosin mediate the interactions
- between the troponin complex and actin so as to regulate muscle contraction.
- The role of tropomyosin in smooth muscle and non-muscle tissues is not clear.
- Tropomyosin is an alpha-helical protein that forms a coiled-coil dimer.
-
- Muscle isoforms of tropomyosin are characterized by having 284 amino acid
- residues and a highly conserved N-terminal region, whereas non-muscle forms
- are generally smaller and are heterogeneous in their N-terminal region.
-
- The signature pattern for tropomyosins is based on a very conserved region in
- the C-terminal section of tropomyosins and which is present in both muscle and
- non-muscle forms.
-
- -Consensus pattern: L-K-E-A-E-x-R-A-E
- -Sequences known to belong to this class detected by the pattern: ALL.
- -Other sequence(s) detected in SWISS-PROT: NONE.
-
- -Note: see also the pattern for the actin binding region shared by muscle-type
- tropomyosins and proteins of the cofilin/destrin family.
-
- -Last update: November 1990 / Text revised.
-
- [ 1] Smilie L.B.
- Trends Biochem. Sci. 4:151-155(1979).
- [ 2] McLeod A.R.
- BioEssays 6:208-212(1986).
-